12.
According to the passage, cytologists in the late nineteenth century were critical of the cell research of biochemists because cytologists believed that
Onescientific discipline, during its early stages of
development, is often related to another as an
antithesis to its thesis. The thesis discipline tends to
concern itself with discovery and classification of
(5) phenomena,to offer holistic explanations
emphasizing pattern and form, and to use existing
theory to explain the widest possible range of
phenomena.The paired or antidiscipline, on the
other hand, can be characterized by a more focused
(10) approach, concentrating on the units of construction,
and by abelief that the discipline can be
reformulated in terms of the issues and explanations
of the antidiscipline.
The relationship of cytology (cell biology) to
(15) biochemistry in the late nineteenth century, when
both disciplines were growing at a rapid pace,
exemplifies such a pattern. Researchers in cell
biology found mounting evidence of an intricate cell
architecture. They also deduced the mysterious
(20) choreography of the chromosomes during cell
division. Many biochemists, on the other hand,
remained skeptical of the idea that so much structure
existed, arguing that the chemical reactions that
occur in cytological preparations might create the
(25) appearance of such structures. Also, they stood apart
from the debate then raging over whether
protoplasm, the complex of living material within a
cell, is homogeneous, network-like, granular, or
foamlike. Their interest lay in the more
(30) “fundamental”issues of the chemical nature of
protoplasm, especially the newly formulated enzyme
theory of life.
In general, biochemists judged to be
too ignorant of chemistry to grasp the basic
(35) processes, whereas cytologists considered the
methods of biochemists inadequate to characterize
the structures of the living cell. The renewal of
Mendelian genetics and, later, progress in
chromosome mapping did little at first to effect a
(40) synthesis.
Both sides were essentially correct. Biochemistry
has more than justified its extravagant early claims
by explaining so much of the cellular machinery. But
in achieving this feat (mostly since 1950) it has been
(45) partially transformed into the new discipline of
molecular biology—biochemistry that deals with
spatial arrangements and movements of large
molecules. At the same time cytology has
metamorphosed into modern cellular biology.Aided
(50) by electron microscopy, it has become more similar
in language and outlook to molecular biology. The
interaction of a discipline and its antidiscipline has
moved both sciences toward a synthesis, namely
molecular genetics.
(55) This interaction between paired disciplines can
have important results. In the case of late nineteenth
century cell research, progress was fueled by
competition among the various attitudes and issues
derived from cell biology and biochemistry. Joseph
(60) Fruton, a biochemist, has suggested that such
competition and the resulting tensions among
researchers are a principal source of vitality and “are
likely to lead to unexpected and exciting novelties
in the future, as they have in the past.”